JNTUK B.Tech Cell Signaling gives you detail information of Cell Signaling R13 syllabus It will be help full to understand you complete curriculum of the year.
UNIT I: INTRODUCTION TO CELL SIGNALING
Introduction; component involved in signalling process. Receptors, ligands, hormones, neurotransmitter, agonist and antagonist. Concept of cell signalling and signal transduction.
LO: To Study basics of intracellular signaling.
LA: Assessment by testing various receptor ligand receptors.
UNIT II: METHODS OF CELL SIGNALLING
Cell signalling and cellular response,Interferon (IFN) signalling,TNF signalling,Methods tostudy cell signaling,Signalling by cell surf ace receptors. Principles of Binding, thermodynamics of Protein–Protein Interactions: Carbohydrate Recognition and Signalling, Protein–Protein Interactions and Conformational Changes.
LO: To study methods of cell signaling and protein interactions and conformational changes associated with it.
LA: Assessment by the ability to demonstrate various methods of cell signaling.
UNIT III: RECEPTORS STRUCTURE AND FUNCTION
Types of receptors: Internal and Trans membrane receptors, Cytokine receptors, G- protein coupled, Hormone receptors, Growth factor receptors and other types of receptors and their function and mechanism of action.
LO: To study the role of receptors its structure and function.
LA: Assessment by demonstrating and differentiating various types of receptors.
UNIT IV: SECONDARY MESSENGERS AND MECHANISM OF ACTION
Different types of hydrophobic molecules, Hydrophilic molecule, Gases etc and mechanism of action.
LO: To study different secondary molecules and its mechanism of action.
LA: Assessment by ability to apply different secondary messengers in cell signaling and demonstrating its mechanism of actions.
UNIT V: CELL SIGNALLING
Cell signaling and differentiation, Cell signalling during development,Transcription factors and cell signalling, Cell signalling and gene expression,Cell signaling and stem cells,RNA-signaling,Cellsignaling during diseases, Cell signalling and biochemical response, Cell adhesion molecules and cell-cellcommunication.
LO: To study various parameters associated with cell signaling.
LA: Assessment by computationally demonstrate various types of cell signaling.
UNIT VI: Defects in Cell signalling
When cell communication goes wrong? Defects in cell signalling treatments. Cell signaling and cancer metastasis.
LO: To study the role of defective signaling
LA: Assessment by computationally testing the defects
TEXT BOOKS
- G. Posil and S.T. Crooke, Mechanism of receptor regulations, Plenum Press,1985.
- R. H Getzenberg and E. E. Bittar, Cell structure and signaling, Elsevier Science, 1997.
- Hand Book of Cell signalling,vol1 Ralph.A.Bradshaw,Academic press 2003.
REFERENCES
- John Hancock, Cell Signaling, 3rd edition, Oxford University Press, 2010.
- Geoffery. M. Cooper & Robert. E. Hausman, The Cell- Molecular approach, 5th edition, Sinauer Associates, 2009.
- Amanda Harvey, Cancer Cell Signalling , Wiley; 1st edition, 2013
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