JNTUK B.Tech Bioinformatics gives you detail information of Bioinformatics R13 syllabus It will be help full to understand you complete curriculum of the year.
UNIT I: INTRODUCTION TO BIOINFORMATICS
Scope of Bioinformatics, Elementary commands and protocols, ftp, telnet, http. Primer on information theory and search tools in bioinformatics.
LO: To understand the scope of bioinformatics and basic protocols.
LA: Assessment by applying basic tools in bioinformatics.
UNIT-II: INTRODUCTION TO HOMOLOGY
Introduction to Homology (with special mention to Charles Darwin, Sir Richard Owen, Willie Henning, Alfred Russel Wallace).
LO: To demonstrate homology with reference to evolution.
LA: Assessment by comparing homology in different species.
UNIT III: SPECIAL TOPICS IN BIOINFORMATICS
DNA mapping and sequencing, Map alignment, Large scale sequencing methods Shotgun and Sanger method.
LO: To understand different mapping and sequencing techniques of DNA.
LA: Assessment by sequencing and mapping DNA of different species.
UNIT IV: SEQUENCING ALIGNMENT AND DYNAMIC PROGRAMMING
Heuristic Alignment algorithms. Global sequence alignments- Neddleman& Wunsch Algorithm Smith-Waterman Algorithm-Local sequence alignments (Amino acid substitution Matrices (PAM, BLOSUM).
LO: To demonstrate different types of alignment and algorithm defining it.
LA: Assessment by computationally aligning the sequences and applying algorithm to it.
UNIT V: PRIMARY, SECONDARY& BIOCHEMICAL DATABASE AND THEIR USE
Introduction to Biological databases, Organization and management of databases. Searching and retrieval of information from the World Wide Web. Structure databases- PDB (Protein Data Bank), Molecular Modeling Databases (MMDB). Primary Databases NCBL, EMBL, DDBJ. Introduction to Secondary Databases Organization and management of databases Swissprot, PIR, KEGG. Introduction to Bio-Chemical databases – organization and Management of databases. KEGG, EXPESY, BRENDA, WIT.
LO: To demonstrate working on primary and secondary databases.
LA: Assessment by searching and retrieving of data from these databases.
UNIT VI: EVOLUTIONARY TREES AND PHYLOGENY
Construction of evolutionary trees. Multiple sequence alignment and phylogenetic analysis.
LO: To understand phylogeny and phylogenetic tree.
LA: Assessment by constructing phylogenetic tree from the given sequences.
TEXT BOOKS
- David Mount, Bioinformatics, 2nd Edition, Cold Spring Harbor Publications, 2004.
- T. K. Attwood, David Parry Smith, Introduction to Bioinformatics, 1st edition, Pearson educations, 2001.
REFERENCES
- Andreas D. Baxevanis, B. F. Francis Ouellette. Bioinformatics – A Practical Guide To The Analysis Of Genes And Proteins, 3rd Edition , Wiley Intrscience Publishers, 2004.
- Harshawardhan P. Bal, Bioinformatics – Principles And Applications, 6th Edition, TATA Mcgraw HILL, 2008.
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