JNTUK B.Tech Biochemical Reaction Engineering–I gives you detail information of Biochemical Reaction Engineering–I R13 syllabus It will be help full to understand you complete curriculum of the year.
UNIT I: FUNDAMENTALS OF REACTION ENGINEERING
Concept of order, molecularity of a reaction, searching a mechanism for a reaction, evaluation of rate constants, factors affecting reaction rates – pH, temperature using Arrhenius equation.
LO: To understand the basics of rate of reaction.
LA: Assessment by evaluating the rate of different reactions.
UNIT II: REACTIONS INVOLVING CELLS – I
Growth Kinetics – batch, fed-batch and continuous mode of operation in reaction system, evaluation of kinetic parameters Monod’s equation- parameters, death rate of cell-batch and continuous sterilization.
LO: To understand the growth kinetics in batch, fed batch, continuous systems.
LA: Assessment by deriving the kinetics.
UNIT III: REACTIONS INVOLVING CELLS -II
Stoichiometry of cell growth and product formation – elemental and available electron balances, degrees of reduction, maintenance coefficient, online data analysis for measurement of biochemical parameters, state and parameter estimation technique.
LO: To study Stoichiometry of cell growth and product formation.
LA: Assessment by Stoichiometry analysis.
UNIT IV: MULTIPLE REACTIONS
Parallel series, series – parallel reactions, calculation of yield and selectivity, role of thermodynamic parameters, metabolic flux analysis, basic concepts of structured model and introduction to cybernetic models, Design principles-non isothermal reactions and pressure effects, concepts of residence time distribution, micro mixing and macro mixing.
LO: To demonstrate the thermodynamic properties & principles of various reactions
LA: Assessment by derivations and calculations.
UNIT V: MECHANISMS AND KINETICS OF ENZYME ACTION
Mechanisms of Enzyme Action: Concept of active site and energetics of enzyme Kinetics, substrate complex formation; Specificity of enzyme action: Kinetics of single substrate reactions, turnover number and estimation of Michaelis-Menten’s parameters. Importance of KM, Multi-substrate reaction mechanisms and kinetics. Types of Inhibition – kinetic models; Substrate and Product Inhibition, Allosteric regulation of enzymes, Deactivation kinetics.
LO: To study the various kinetics and inhibitions of enzymes.
LA: Assessment by deriving the kinetics and demonstrating the inhibitions of enzymes.
UNIT VI: MASS TRANSFER EFFECTS IN IMMOBILIZED ENZYME
Brief overview of immobilization techniques: Immobilization techniques, Influence of different parameters on Immobilized reaction kinetics. Analysis of Film and Pore Diffusion Effects on kinetics of Immobilized Enzyme Reactions, calculation of Effectiveness Factors, Thiele modulus.
LO: To demonstrate the Mass Transfer Effects in Immobilized Enzyme.
LA: Assessment by deriving the kinetics of diffusion.
NOTE: In all units relevant basic numerical problems should be practiced.
TEXT BOOKS
- Harvey W. Blanch, Douglas S. Clark, Biochemical Engineering, Marcecel Dekker, 2007.
- O. Levenspiel, Chemical Reaction Engineering, 3rd edition, wiley, Newyork, 1998.
- P. M. Doran Bioprocess Engineering principles, 2nd edition, academic Press, London, 2012.
- D. G. Rao, Introduction to Biochemical Engineering, 2nd edition, McGraw-Hill, 2005
- K. A. Gavhane, Chemical Reaction Engineering–I, 2nd edition, Nirali Prakashan, 2006.
- J. Nielsen, J. Villadsen and G. Liden Bioreaction Engineering Principles, Springer International, 2nd edition, 2003.
- G. Hammes, Thermodynamics and kinetics for the biological sciences, 2nd edition, Wiley – VCH, 2000
REFERENCES
- H. Scott Fogler, Elements of Chemical Reaction Engineering, 4th Edition, Prentice Hall of India Pvt. Ltd, 2005.
- J. M. Smith, Chemical Engineering Kinetics, 3rd edition, McGraw Hill, 1981.
- M. L. Shuler and F. Kargi Bioprocess Engineering: basic concepts, 2nd edition, TBS Publishers, 2001.
- H. J. Fromm Initial rate Enzyme kinetics, reprint Springer-verlog, 1st edition, Berlin 2012.
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