JNTUK B.Tech Bio assays & Toxicology gives you detail information of Bio assays & Toxicology R13 syllabus It will be help full to understand you complete curriculum of the year.
Unit I: Basic principles of Bioassays, merits and demerits, methods of bioassays. Test for pyrogens and test for freedom undue toxicity.
LO : To gain knowledge on bioassays and its applications, its importance and need in the present context.
UNIT II : Bioassays of digoxins, posterior pituitary extract, Insulin and tetanus anti toxin.
LO : Principles and procedures involved in bioassays and their limitations.
UNIT III :History, scope of toxicology, principles of toxicology, mechanisms and risk assessment, biotransformation of xenobiotics and toxicokinetics.
LO : To grasp knowledge on scope, principles , mechanisms and risk assessment.
UNIT IV :Acute toxicity, subacute toxicity and chronic toxicity, Determination of LD50. Chemical Carcinogens: Definitions, mechanisms of action of chemical carcinogens, Test systems for carcinogenicity assessment, Chemical carcinogenesis in humans.
LO : To get an overview on acute, sub-acute and chronic toxicity studies, Carcinogenicity and chemical carcinogenesis in humans.
UNIT V : Target Organ Toxicity:
- Toxic responses of the blood.
- Toxic responses of the liver.
- Toxic responses of the kidney.
- Toxic responses of heart and vascular system.
- General Principles of Poisoning: Signs, symptoms, treatment of acute and chronic
- poisoning due to heavy metals, snake venom.
LO : To acquire knowledge on toxic responses of target organs, poisoning and its treatment strategies.
UNIT VI : Toxic Agents:
- Toxic effects of pesticides.
- Toxic effects of metals.
- Toxic effects of solvents and vapours.
- Toxic effects of plants.
LO : To learn about intoxication produced by various toxicants.
Text Books
- Casarett&Doull’s Toxicology The Basic Science of Poisons, Seventh edition. Editor- Curtis D. Klaassen, Ph.D.
- Niesink R.J.M. de Vries J and Hollingers M.A. Toxicology, Principal and Applications, CRC Press1996.
- Harrisons Principles of Internal Medicine. Medical Toxicology (Ellen Horns).
- Toxicology – Principles and Applications, Raymond J.M.Niesink, John de.Vries, Mannfred A. Hollinger.
- Basis of Toxicology Testing Edited by Douald J Ecobichon.
- Ellenhorns Medical toxicology 2nd Edition Williams and Wilkins, Baltimore, 1997.
- Goldfrank’s Toxicological Emergencies, ninth edition.
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