Medicinal Chemistry \u2013 I Detailed Syllabus for B.Tech third year second sem is covered here. This gives the details about credits, number of hours and other details along with reference books for the course.<\/p>\n
The detailed syllabus for Medicinal Chemistry \u2013 I B.Tech 2016-2017 (R16) third year second sem is as follows.<\/p>\n
B.Tech. III Year II Sem. \u00a0 L\/T\/P\/C
\nCourse Code:PS601 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a04\/1\/0\/4<\/p>\n
Course Objectives<\/strong>: The basic consideration of drug activity, drug metabolism and medicinal\u00a0substances belonging to different categories are discussed in an elaborative manner. The synthesis\u00a0and mechanism of action of the medicinal compounds are explained in an organized way which helps\u00a0the students to understand the medicinal uses of the compounds.<\/p>\n Course Outcome:<\/strong> The students gain good knowledge about the usage of medicinal substances, the\u00a0synthesis and drug-drug interactions, so that they can get involved with confidence in the patient\u00a0counseling.<\/p>\n UNIT I<\/strong> UNIT II\u00a0Drugs acting on CNS: A brief study of the chemistry of neurotransmitters.<\/strong> UNIT III<\/strong><\/p>\n
\na. Basic considerations of Drug activity:<\/strong> Physico chemical properties of drug molecules in relation\u00a0to biological activity \u2013 Solubility, lipophilicity, partition-coefficient, Ionization, hydrogen bonding,\u00a0Chelation, redox potential and surface activity. Bioisosterism and steric features of drugs, drug\u00a0distribution and protein binding: Introduction to Pro and soft drug approaches.
\nb. Drug metabolism and inactivation:<\/strong> Introduction, Phase-I and Phase-II reactions.
\nNote:<\/strong> Introduction, definition, nomenclature, chemical classification, structure, synthesis,\u00a0general mechanism, and mode of action, SAR including physicochemical and stereo chemical\u00a0aspects, metabolism and therapeutic uses of the drugs from each category shall be studied for\u00a0the following units. An outline of synthetic procedure of only the drugs mentioned in each\u00a0category.<\/p>\n
\na. Hypnotics and Anxiolytics:<\/strong> Phenobarbital, diazepam, alprazolam, glutethimide
\nAnti-psychotics: Chlorpromazine, haloperidol, clozapine, oxypentine.
\nAnti-epileptics: Phenytoin, valproic acid, carbamazepine, ethosuximide.
\nAnti-depressants: Imipramine, fluoxetine, doxepine
\nb. Local anesthetic and General anesthetic agents:<\/strong> benzocaine, procaine, dibucaine and\u00a0lidocaine, halothane and thiopental sodium.<\/p>\n\n
\nephedrine, salbutamol,<\/li>\n
\nCholinergics: Carbachol, bethanichol
\nAnticholinesterase: Neostigmine, pyridostigmine
\nNeuromuscular blockers: succinyl choline.<\/li>\n