Pharmacokinetics And Drug Metabolism Detailed Syllabus for Pharmacology M.Pharm first year first sem is covered here. This gives the details about credits, number of hours and other details along with reference books for the course.
The detailed syllabus for Pharmacokinetics And Drug Metabolism M.Pharm 2017-2018 (R17) first year first sem is as follows.
M.Pharm. I Year I Sem.
Course Objective: In current methods of treatment which involves individualization of drug therapy, the student should have sound knowledge in pharmacokinetics and the effects of changes in pharmacokinetic parameters on therapeutic efficacy of the drugs
Course Outcomes: Upon completion of the subject student shall be able to (Know, do, appreciate) –
- understand various pharmacokinetic parameters
- influence of these parameters on efficacy of drugs
- identify and resolve drug related problems;
- pharmacogenetics
UNIT – I : Drug Absorption: Gastrointestinal, percutaneous, and rectal kinetics and factors affecting drug absorption. Absorption kinetics
UNIT – II : Drug Distribution: Plasma protein binding – factors affecting plasma protein binding – Tissue binding – transfer of drugs through biological barriers their therapeutic implication in drug action. Volume of distribution. Reaction of the body to foreign substances: Biotransformation of drugs, phase I and phase II metabolic reactions.
UNIT – III : Elimination of drugs: Concept of renal clearance and excretion of drugs –biological half – life, area under curve.
UNIT – IV : Bioavailability of drug products: Bioavailability tests. Bioequivalence. Compartment models and relevant pharmacokinetic parameters.
UNIT – V : Pharmacogenetics: Inter racial and individual variability in drug metabolism.
REFERENCES:
- Shargel and Leon. Applied Biopharmaceutics and pharmacokinetics. Latest edition. Publisher: Prentice Hall, London.
- Biopharmaceutics and Clinical Pharmacokinetics by, Milo Gibaldi b. Remington’s Pharmaceutical Sciences, By Mack Publishing Company, Pennsylvnia.
- Pharmacokinetics: By Milo Glbaldi Donald, R. Mercel Dekker Inc.
- Hand Book of Clinical Pharmacokinetics, By Milo Gibaldi and Laurie Prescott by ADIS Health Science Press.
- Biopharmaceutics and Pharmacokinetics; By Robert F Notari f. Biopharmaceutics; By Swarbrick
- Biopharmaceutics and Pharmacokinetics-A Treatise, By D. M. Brahmankar and Sunil B. Jaiswal, Vallabh Prakashan Pitampura, Delhi
- Cilincal Pharmacokinetics, Concepts and Applications: By Malcolm Rowland and Thomas, N. Tozer, Lea and Febrger, Philadelphia, 1995.Dissolution, Bioavailability and Bioequivalence, By Abdou H.M, Mack, Publishing Company, Pennsylvania 1989.
- Biopharmaceutics and Clinical Pharmacokinetics-An introduction 4th edition Revised and expanded by Robert F Notari Marcel Dekker Inn, New York and Basel, 1987.
- Encyclopedia of Pharmaceutical Technology, Vol 13, James Swarbrick, James, Roylan, Marcel Dekker Inc, New York 1996.
For all other M.Pharm 1st Year 1st Sem syllabus go to JNTUH M.Pharm Pharmacology 1st Year 1st Sem Course Structure for (R17) Batch.
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