Medicinal Chemistry – I Detailed Syllabus for B.Tech third year second sem is covered here. This gives the details about credits, number of hours and other details along with reference books for the course.
The detailed syllabus for Medicinal Chemistry – I B.Tech 2016-2017 (R16) third year second sem is as follows.
B.Tech. III Year II Sem. L/T/P/C
Course Code:PS601 4/1/0/4
Course Objectives: The basic consideration of drug activity, drug metabolism and medicinal substances belonging to different categories are discussed in an elaborative manner. The synthesis and mechanism of action of the medicinal compounds are explained in an organized way which helps the students to understand the medicinal uses of the compounds.
Course Outcome: The students gain good knowledge about the usage of medicinal substances, the synthesis and drug-drug interactions, so that they can get involved with confidence in the patient counseling.
UNIT I
a. Basic considerations of Drug activity: Physico chemical properties of drug molecules in relation to biological activity – Solubility, lipophilicity, partition-coefficient, Ionization, hydrogen bonding, Chelation, redox potential and surface activity. Bioisosterism and steric features of drugs, drug distribution and protein binding: Introduction to Pro and soft drug approaches.
b. Drug metabolism and inactivation: Introduction, Phase-I and Phase-II reactions.
Note: Introduction, definition, nomenclature, chemical classification, structure, synthesis, general mechanism, and mode of action, SAR including physicochemical and stereo chemical aspects, metabolism and therapeutic uses of the drugs from each category shall be studied for the following units. An outline of synthetic procedure of only the drugs mentioned in each category.
UNIT II Drugs acting on CNS: A brief study of the chemistry of neurotransmitters.
a. Hypnotics and Anxiolytics: Phenobarbital, diazepam, alprazolam, glutethimide
Anti-psychotics: Chlorpromazine, haloperidol, clozapine, oxypentine.
Anti-epileptics: Phenytoin, valproic acid, carbamazepine, ethosuximide.
Anti-depressants: Imipramine, fluoxetine, doxepine
b. Local anesthetic and General anesthetic agents: benzocaine, procaine, dibucaine and lidocaine, halothane and thiopental sodium.
UNIT III
- Adrenergic agents and adrenergic blockers.Isoproterenol, atenolol, henoxybenzamine, amphetamine,
ephedrine, salbutamol, - Cholinergic agents and acetyl cholinesterase inhibitors
Cholinergics: Carbachol, bethanichol
Anticholinesterase: Neostigmine, pyridostigmine
Neuromuscular blockers: succinyl choline. - Anti-cholinergics: atropine, ipratropium bromide, dicyclomine, bipyridine, propantheline
TEXT BOOKS:
- William O. Foye, Textbook of Medicinal Chemistry, Lea Febiger, Philadelphia.
- JH Block & JM Beale (Eds), Wilson & Giswold’s Text book of organic Medicinal Chemistry and pharmaceutical chemistry, 11th Ed, Lipcott, Raven, Philadelphia, 2004.
- Medicinal Chemistry by Korol Kavas.
REFERENCES
- D. Abraham (Ed), Burger Medicinal chemistry ad Drug discovery, Vol. 1 & John Wiley & Sons, New York 2003, 6th Ed.
- Daniel lednicer, Strategies for Organic Drug Synthesis and Design, John Wiley, N. Y. 1998
For all other B.Tech 3rd Year 2nd Sem syllabus go to JNTUH B.Tech B. Pharm 3rd Year 2nd Sem Course Structure for (R16) Batch.
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