JNTUH B.Pharm 2nd year (R13202) Pharmaceutical Organic Chemistry – II gives you detail (R13202) Pharmaceutical Organic Chemistry – II Engineering R13 year subject. It will be help full you to understand you complete curriculum of the year.
Objective
The chemistry of highly complicated organic compounds like polynuclear hydrocarbons and heterocyclic compounds are discussed along with their stereochemical aspects
Note: Definition, nomenclature, structure, aromaticity, reactivity, acidity-basicity and characteristic reactions of the following heterocyclic compounds.of Unit I and II Few Examples of Drugs which contain the cited ring system.
UNIT I
Five membered and six membered ring systems with one hetero atom: Furan, pyrrole, thiophene and pyridine.
Fused ring systems with one hetero atom: Indole, quinoline, iso-quinoline, and acridine.
UNIT II
Five membered and six membered ring systems with two heteroatoms: Pyrazole, imidazole, oxazole, isoxazole, thiazole, pyrazine, pyrimidine and pyridazine. Fused ring systems with two heteroatoms: Benzimidazole and phenothiazine, Cinnoline, Quinazoline and Quinoxaline.
UNIT III
Stereo chemistry of Carbon compounds: Optical rotation, plane polarized light, optical activity, chirality, notations (assignment of configuration), relative configuration (Fischer DL configuration), absolute configuration (R & S), sequence rules (with examples), enantiomers, meso compounds, racemic mixture, resolution. Stereochemistry of alkenes: Concept of E & Z configurations.Elements of symmetry.
Outcome
As the structural and stereochemical aspects and chemistry of organic compounds are discussed, it would help the students to have a good command over structural composition of organic compounds to evaluate and analyze the chemistry of these compounds
TEXT BOOKS
- R Morrison and R. Boyd, organic chemistry, Pub by Printice Hall of India, New Delhi.
- I L Finar, Organic Chemistry, Vol. I. & II, 6th Pearson education
- Reagents & reaction by O.P Agarwal
- Oraganic reactions,Stereo chemistry&mechanizam by PS Kalsi
REFERENCES
- Jerry March, Advanced Organic Chemistry 4th Ed.
- Cram & Hammond.Organic Chemistry.
- A.I. Vogal, A textbook of practical organic chemistry
- Solomons, Organic Chemistry
- Eliel, Stereochemistry of Organic compounds.
- Arun Bahl & S.S Bahl, Advanced Organic Chemistry.
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